New York City Get Printable Handwriting Hear It! Say It! Write It! Learn It! Spelling Test Definition noun. the largest city in New York State and in the United States; located in southeastern New York at the mouth of the Hudson river; a major financial and cultural center Example Sentence I went to college in New York City. Synonyms NYC; Big Apple; Manhattan Antonyms farm Hear It! Say It! Write It! New York City Switch to cursive Start Share with your friends: